Signal transduction pathways and transcriptional regulation in Th17 cell differentiation

Transcriptional regulatory networks in Th17 cell differentiation.

Upon encountering antigen in the context of antigen presenting cells, naïve CD4(+) T cells undergo differentiation into effector T helper (Th) cells, which can secrete high levels of cytokines and other immunomodulators to mediate host defense and tissue inflammation. During the past three years, the immunology field has witnessed an explosion of research advances in the biology of Th17 cells, ...

Signal transduction pathways regulating hematopoietic differentiation.

Modeling signal transduction pathways and their transcriptional response

PRDM Proteins: Molecular Mechanisms in Signal Transduction and Transcriptional Regulation

PRDM (PRDI-BF1 and RIZ homology domain containing) protein family members are characterized by the presence of a PR domain and a variable number of Zn-finger repeats. Experimental evidence has shown that the PRDM proteins play an important role in gene expression regulation, modifying the chromatin structure either directly, through the intrinsic methyltransferase activity, or indirectly throug...

Signal transduction pathways leading to spore differentiation in Dictyostelium discoideum.

Cells that overexpress PKA as a consequence of carrying multiple copies of the gene encoding the catalytic subunit can be induced to sporulate when developing as single cells. A peptide phosphorylated by PKA, termed SDF-1, has recently been shown to stimulate this process (Anjard et al., 1997). Several genes have been implicated in a signal transduction pathway by which prestalk cells induce en...